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But you don't know if the new drug is going to be better or worse. Sometimes the placebo arm has a better outcome than the drug arm.

And, unfortunately, sometimes they really mess up the statistics. Consider that huge trial from some years ago that declared hormone replacement for menopause symptoms definitely bad. No, despite the huge size of the study they made a fundamental mistake in recruiting participants--all that study actually proved is what was long known: fat women shouldn't be on hormone replacement.




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