We currently don’t know how to calculate the nucleus’s bound state despite a thorough understanding of individual pieces that make it together, as explored in colliders like CERN and others. The problem is similar to telling at what temperature water is boiling, freezing, and its density from knowing the properties of a single water molecule. We understand quantum mechanics and Columb forces govern the properties; it is incredibly hard to renormalise the system from an energy scale of a gas to a liquid or solid. Similarly, it is for a quark-gluon plasma; thus, phenomenological models are used, like how the nuclear potential could look and the masses for different combinations of nuclei.