If you open the demos in a browser like Safari that doesn't support the feature, the demos remain as normal grid-aligned cells.
There I realize that masonry mainly works when your cells have such different heights that to grid-align them creates a lot of vertical dead space. Images and news blocks with images make sense for masonry for this reason and it feels good.
But text-only cells where the cell heights don't differ much, they seem better without masonry. The megamenu demo also works much better as a normal grid because they start with a header so grid alignment lets you scan the headers left to right easily.
A text-only newspaper could make sense with masonry because you aren't trying to navigate relationships between the items, and presumably the content can vary the cell height a lot.